Alzheimer's disease research takes 'major leap forward'

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Alzheimer's disease research takes 'major leap forward'

More than 40 genes have been linked to Alzheimer's disease for the first time, in a "landmark" study offering hope for better diagnosis and treatment.

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Scientists in eight countries, including specialists at Cardiff University, looked at genetic material of 111,000 people with Alzheimer's.

Findings suggest it is caused by many factors with evidence for a specific protein involved in inflammation.

Study co-author Prof Julie Williams said it was "a major leap forward".

"Genetics has and will continue to help us identify specific disease mechanisms which we can target therapeutically," said Prof Williams, centre director at the UK Dementia Research Institute at Cardiff University.

Alzheimer's disease is the most common cause of dementia and affects more than 850,000 people in the UK.

The research team hopes that, in future, genetic testing will identify those most at risk of developing Alzheimer's before symptoms appear.

The study, published in Nature Genetics, identified 75 genes associated with an increased risk of developing Alzheimer's disease, including 42 genes not previously implicated in the condition.

It also confirmed previous findings regarding the proteins amyloid-beta and tau, which build up in and around nerve cells as Alzheimer's progresses, and found that inflammation and the immune system play a role in the disease.